For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). ... that binds to proprotein convertase subtilisin kexin type 9 (PCSK9). This class of drug can be given with statins and is usually for people at high risk of heart disease who have not been able to lower their cholesterol enough through other means. They are not Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Absolute bioavailability: 85%. Select one or more newsletters to continue. PCSK9 Inhibitors. What are the names of PCSK9 inhibitors? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Important: The information below refers to products available in the United States that contain alirocumab. Brand names: PraluentDrug class(es): PCSK9 inhibitorsAlirocumab systemic is used in the treatment of: → Search the entire Drugs.com site for alirocumab. They are sold under the brand names Repatha and Praluent. Right now, there are two FDA-approved medications: alirocumab (Praluent) and evolocumab ( Repatha ). The ones are can be used in the UK are Evolocumab and Alirocumab. Two PCSK9 inhibitors are currently available in the UK and others are in the process of being developed. Peak plasma time: 3-7 days. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Alirocumab is a PCSK9 inhibitor produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme that binds to low-density lipoprotein receptors (LDL receptors), which stops LDL being removed from the blood, leading to an increase in blood levels of LDL. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. They are not Description and Brand Names. Vd: 0.04-0.05 L/kg ... that targets proprotein convertase subtilisin kexin type 9 (PCSK9). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The only one on the market is the drug ezetimibe, available as a generic or as the name-brand Zetia. Repatha; Descriptions. We comply with the HONcode standard for trustworthy health information -. For You News & Perspective ... More than 7100 monographs are provided for prescription and over-the-counter drugs, as well as for corresponding brand-name drugs, herbals, and supplements. Drug information provided by: IBM Micromedex US Brand Name. They are sold under the brand names Repatha and Praluent. PCSK9 is a serine protease that destroys LDLR in the liver, resulting in decreased LDL-C clearance and increased plasma LDL-C. PCSK9 inhibitors decrease LDLR degradation by PCSK9, and thereby improve LDL-C clearance and lower plasma LDL-C. Absorption. Two PCSK9 inhibitors are currently available in the UK and others are in the process of being developed. PCSK9 inhibitors. PCSK9 inhibitors are a new class of drugs that lower LDL, or “bad,” cholesterol. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Brand Name and Other Names: Praluent Generic Name: Alirocumab Drug Class: PCSK9 Inhibitors. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. PCSK9 Inhibitors: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from Medscape Reference. They also appear to lower the risk of serious heart-related events by 15%. Available for Android and iOS devices. This drug can be combined with statins to produce faster results. Potent cholesterol-lowering drugs known as PCSK9 inhibitors lower harmful LDL cholesterol by more than 50%. Available for Android and iOS devices. PCSK9 inhibitors may provide another treatment option … Brand Name: Praluent; Last reviewed on RxList: 3/20/2020. Two other PCSK9 inhibitors are still being developed. List of PCSK9 inhibitors: View by Brand … Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Distribution. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Drug images are also included. They also appear to lower the risk of serious heart-related events by 15%. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. What Is Alirocumab Used For and How Does it Work? PCSK9 inhibitors are designed to attach to a particular liver protein, which results in lowered LDL cholesterol. We comply with the HONcode standard for trustworthy health information -, Search the entire Drugs.com site for alirocumab. The ones are can be used in the UK are Evolocumab and Alirocumab. They block the PCSK9 protein's ability to work, which helps the liver get rid of more bad cholesterol from … The PCSK9 inhibitor blocks the PCSK9 enzyme, resulting in more LDL receptors available to remove LDL from the blood, which produces in a decrease in LDL blood levels. They’re available in brand name and generic tablets and have become quite affordable. Two other PCSK9 inhibitors are still being developed. What are the names of PCSK9 inhibitors? The PCSK9 inhibitor blocks the PCSK9 enzyme, resulting in more LDL receptors available to remove LDL from the blood, which produces in a decrease in LDL blood levels. Potent cholesterol-lowering drugs known as PCSK9 inhibitors lower harmful LDL cholesterol by more than 50%. PCSK9 Inhibitors may be used along with diet and statin medications to lower low-density lipoprotein (LDL) cholesterol (also known as "bad cholesterol"). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Products available in the UK are Evolocumab and alirocumab, Side Effects, interactions, Patient Handouts Pricing! 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